Ligases Enzyme Market

Ligases Enzyme Market Size, and Business Strategies

The ligases enzyme market revenue will be $631.7 million by 2030, growing from $367.4 million in 2021 at a 6.2% CAGR. This is attributed to the growing usage of these chemicals in the detection of infectious diseases and genetic abnormalities, along with the booming cancer burden.

North America Generates Highest Revenue, Led by U.S.

    The highest revenue in the market, of $224.7 million, was generated in North America last year. The extensive R&D activities in disease diagnostics and treatment using these enzymes will allow the region to keep dominating the market over this decade.

    A hub for biotechnology, the region is witnessing an increasing usage of these agents in protein engineering, PCR, cloning, mutation detection, drug target, and NGS.

    The U.S. holds the larger share in the ligases enzyme market of North America, due to the high incidence of genetic defects and a rise in the number of people needing long-term care. Additionally, the government efforts aimed at the utilization of ligases enzymes in molecular diagnosis tools drives the country’s market.


T4 DNA ligases, the largest category, will witness a 6.8% CAGR, the highest within the product segment. T4 DNA is used for the effective and quick ligation of blunt double-stranded as well as cohesive-ended DNA fragments during molecular diagnoses; it is also used for T/A cloning.


Considered a highly flexible ligase, T4 DNA is the popular choice in the majority of traditional molecular cloning procedures. T4 DNA offers effective ligation in high temperatures and media with high salt concentrations. Additionally, this biological agent achieves ligation in merely 5 minutes at room temperature, with the use of a specialty optimized buffer.


With revenue of $135.5 million, research laboratories and institutions lead the ligases enzyme market on the basis of end user. This is attributed to the role of these institutions in biotechnology research, which brings about innovations in the domain of genetic testing. Moreover, research labs are extensively working to discover the biological and chemical modulators of ligases enzyme targets with regulatory approval.


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